The present invention relates to stable amorphous 3-De[(26-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-1112-dideoxy-6-O-methyl-3-oxo-1211-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin (telithromycin) methods for the preparation thereof the use of stable amorphous telithromycin in the treatment of bacterial infections and to pharmaceutical compositions comprising stable amorphous telithromycin.

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