The invention discloses a kind of two protection ertapenem xln and preparation method thereof described two protection ertapenem xln have powder x-ray diffraction spectrogram shown in Figure 1.The preparation of this xln is at first to make carbapenem parent nucleus MAP and ertapenem side chain carry out condensation reaction reaction finishes pouring reaction solution into the pH value is in the mixed solvent that forms of 4～6 damping fluid and esters solvent extracting and demixing then add the damping fluid washing in organic layer; Organic layer with after anhydrous sodium sulfate drying filtration in 0～30 ℃ of stirring and crystallizing filters washing leaching cake vacuum-drying.Two protection ertapenem xln good stability provided by the invention purity is high for follow-up preparation high purity stay-in-grade ertapenem are laid a good foundation and assurance is provided; And preparation method of the present invention is simple and raw material is cheap and easy to get is easy to realize mass-producing meets industrialization production requirements has practical reference value.

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