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专利详细信息
专利号
CN103570720A
专利标题 A kind of meropenem bulk drug, its preparation method and the pharmaceutical composition that comprises it
专利权人
发明人
申请号 CN20121276503
申请日 2012/7/31
公开日 2014/2/12
优先权号
IPC C07D47720000;
专利类型
法律状态查询 查看法律状态


The invention discloses a kind of meropenem bulk drug it is characterized in that by weight percentage in described bulk drug the content of meropenem is 98.0%~101.0% with anhydride calculates; In the related substance of described bulk drug impurity A impurity B are all not more than 0.25%; The single impurity of any the unknown is not more than 0.05%; Except A and B other impurity summation is not more than 0.25%; The residual 300ppm that is not more than of acetone.The invention also discloses a kind of meropenem pharmaceutical composition of injection it is activeconstituents that this pharmaceutical composition be take meropenem bulk drug provided by the invention has good stability.Meropenem bulk drug purity provided by the invention is high impurity situation is clear solvent residual low solvability good extended storage stability good can guarantee medicine effectively safety.
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