The present invention provides a method of preventing and/or treating a wound infection by introducing to a wound a clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of vancomycin gentamicin and a mixture thereof water a phospholipid an oil a pH adjusting agent and a viscosity modifying agent wherein the water present in the viscous depot is no more than about 4 wt % no more than about 2 wt % or no more than about 0.5 wt % of water relative to the total weight of the depot.

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