The invention provides a kind of phosphorylation and prepare the vidarabine phosphate method; specifically; be starting raw material with the vidarabine through protection of inert gas under the effect of acid binding agent and catalyzer after phosphorylation namely get the crude product vidarabine phosphate by aftertreatments such as activated carbon decolorizings; this operational path is simple; cost is low and the yield height is with respect to prior art; production process toxicity reduces greatly is fit to technology production.

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