The invention discloses an 8-cyclohexyl-2-fluoro-vidarabine a preparation method thereof and an application of 8-cyclohexyl-2-fluoro-vidarabine to treatment of leucocythemia. By using a synthesis method disclosed by the invention a heavy metal catalyst in the current synthesis method is avoided the synthesis operation is simplified heavy metal residues in 8-cyclohexyl-2-fluoro-vidarabine are avoided and the preparation method is suitable for research and further large-scale preparation of drugs.

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