The present invention relates to a kind of cefadroxil benzyl compound and method for making thereof that comprises following treatment step: step 1) in the raw material S 578 add ethanol or ether the control temperature is no more than 30 ℃ vigorous stirring filter then filter cake is no more than 15 ℃ ethanol or ether with temperature and washs and vacuum-drying or air dry; Step 2) filter cake is put into ammoniacal liquor mild stirring control pH value is no more than 9 obtains the ammonia soln of S 578 then the throw out of separating out is filtered out; Step 3) slowly adding concentration in the ammonia soln of S 578 is the hydrochloric acid of 1-3mol/L temperature control is at 30-60 ℃ and final pH is controlled at 4.0-6.0 keeps 30 minutes to 5 hours slowly there is crystal to separate out progressively temperature is reduced to minimum 10 ℃ then leaves standstill crystallization suction filtration vacuum-drying gets the S 578 elaboration; Step 4) the optional crystalline mother solution that will separate out after the crystallization returns step 3).The inventive method has improved the purity of S 578 greatly and has significantly reduced its related substances has improved the quality of formulation products has reduced toxic side effect.

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