The invention discloses 4-dedimethylamino tetracycline and/or its derivant purposes in the medicines such as preparation treatment HP infected disease and medical apparatus sterilizing.The present invention also provides a kind of medicine for the treatment of Helicobacter pylori infection associated diseases and this medicine can adopt the dosage form of tablet capsule ointment varnish aerosol.4-dedimethylamino tetracycline and/or its derivant can not develop immunity to drugs and can utilize anti-helicobacter pylori the antiinflammatory of this medicine the function of anti-metalloproteases alleviates or cure the Other diseases of HP infected gastritis and Helicobacter pylori infection.

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