7-Disubstituted-phenyl tetracycline compounds are disclosed herein. Also disclosed is a method for treatment or prevention of spinal muscular atrophy using the 7-disubstituted-phenyl tetracycline compounds. This invention also relates to a method for treating or preventing a subject having spinal muscular atrophy. The method includes administering to the subject an effective amount of a tetracycline compound of formula (1 ) such that the spinal muscular atrophy is treated or prevented. Advantageously the tetracycline compounds used in this method of the invention have one or more of the following characteristics: 1 ) potency in modulating mRNA splicing 2) potency in modulating SMN protein levels 3) central nervous system (CNS) and/pr brain penetration 4) decreased phototoxic properties and 5) decreased antibacterial properties.

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