The present invention relates to compositions for the modulation of inflammation in connective tissues in humans and animals and the modulation of markers of such inflammation including COX-2 TNF-a IL-1 (3 iNOS p38 and chemokines comprising any or all of anabolic anti-catabolic anti-oxidant and analgesic agents including aminosugars S-adenosylmethionine arachadonic acid GAGs including pentosan collagen type II tetracyclines or tetracycline-like compounds diacerin super oxide dismutase L-ergothioneine methyl sulfanylmethane one or more avocado/soybean unsaponifiables and an analgesic e.g. acetaminophen and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

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