Aerosol compositions used for anesthetizing mammals in both human and veterinary applications include prilocaine base solubilized in the hydrofluorocarbon (HFC) propellants 1112-tetrafluoroethane and 1112333-heptafluoropropane. Prilocaine base has been found to be readily soluble in HFC propellants when combined in liquid or micro rod form and a solution stable to temperatures as low as -82 DEG C. is formed upon combination of the two components. In the aerosol compositions the HFCs are the only propellants used. Additional pharmaceutical constituents can also be combined the the prilocaine base/HFC composition to provide a multi-component anesthetic and it has been found that the presence of prilocaine in the combination can assist in solubilizing and/or suspending these pharmaceutical consituents. Some example pharmaceutical compositions within the practice of this invention include HFC prilocaine base and a pharmaceutical other prilocaine selected from the group consisting of bronchodilators antiinflammatories antitusives vasoactive drugs vasoconstrictors antibiotics peptides steroids enzymes antihistamines hormones enzyme and receptor inhibitors and agonists 5-aminolevulinic acid antiseptics disinfectants procaine cocaine chloroprocaine tetractaine mepivacaine lidocaine bupivacaine etidocaine ropivacaine benzocaine and phenylephrine.

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