The invention belongs to medical technical field be specifically related to the Tigecycline derivative shown in general formula (I) its pharmacy acceptable salt its prodrug its solvate or its isomer wherein R2a R2b R3 R4a R4b R5 R6a R6b R7 R8 R9a R9b R10 R11 R12 R13 X and W be as defined in specification sheets; The invention still further relates to the preparation method of these compounds the pharmaceutical composition that contains these compounds and these compounds treat and/or prevent the application in the disease medicament of tetracycline medication sensitivity in preparation.

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