The invention discloses compound telithromycin nanoemulsion oral liquid. The grain size of the oral liquid ranges from 1nm to 100nm, the compound telithromycin nanoemulsion oral liquid is prepared by raw materials including, by mass percent, from 35 to 45% of surface active agent, from 1 to 5% of cosurfactant, from 4 to 12% of oil phase, from 1 to 3.5% of telithromycin, from 0.1 to 0.3% of bromhexine hydrochloride and the balance deionized water, and the sum of the mass percents of the raw materials is 100%. The telithromycin is the first and the uniquely listed ketolide medicine in the worldat present, and has broad-spectrum antibiotic activity, lower selective drug resistance and cross drug resistance with other ketone antibiotics

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