专利详细信息
| 专利号 |
 |
| 专利标题 | Method for reversing drug resistance of breast cancer by using miR-487a |
| 专利权人 | WEI MINJIE; |
| 发明人 | WEI MINJIE;HE MIAO;MA MENGTAO;ZHAO LIN;BAI XUEFENG;YU ZHAOJIN;SUN MINGLI;CHEN QIUCHEN; |
| 申请号 | CN2013150665 |
| 申请日 | 2013/2/7 |
| 公开日 | 2013/8/28 |
| 优先权号 | |
| IPC | A61K48/00; A61P35/00; |
| 专利类型 | |
| 法律状态查询 | 查看法律状态 |
The invention belongs to the field of medicines for treating cancer, and in particular relates to a method for reversing drug resistance of breast cancer by using miR-487a. The method comprises the following steps: (1) inhibiting BCRP (Breast Cancer Resistance Protein) expression and drug transport function in drug resisting cells MCF-7/MX of breast cancer by means of a stimulant miR-487amimic of miR-487a, and increasing sensitivity to a BCRP transfer substrate mitoxantrone hydrochloride
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