The invention provides a metoprolol tartrate sustained release tablet. The metoprolol tartrate sustained release tablet is prepared from the following components in percentage by mass: 100 of metoprolol tartrate, 60-80 of retardant, 20-40 of filling agent, 2-10 of lubricating agent, 50-90 of adhesive and 2.5-4 of film coating powder. Aiming at the problem that adhesive brewing is easily caused in production because the metoprolol tartrate is easy to dissolve in water, the invention provides a two-step granulation method comprising the steps of respectively preparing medicine contained granules and blank granules, drying the medicine contained granules and the blank granules, totally mixing the medicine contained granules and the blank granules and tabletting, so that the problem of adhesive brewing in tabletting is solved. In addition, the metoprolol tartrate is strong in moisture absorption property and bitter in taste, and a coating layer can be used for improving the stability of the metoprolol tartrate and masking the bitter taste of the metoprolol tartrate. The metoprolol tartrate sustained release tablet has the advantages that the components of the auxiliary materials are simple, the operation is convenient, the prepared granules are good in flowability, strong in adhesive resistance and incapable of causing adhesive brewing during tabletting, and the coating layer can be used for improving the stability of a drug and masking the bitter tastes of active ingredients and has no affect to the release rate of the tablet. The metoprolol tartrate sustained release tablet is suitable for industrial production and relatively high in application value.

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