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专利详细信息
专利号
CN103467355A
专利标题 Preparation method of indapamide
专利权人 DISHA PHARMACEUTICAL GROUP CO LTD;WEIHAI DIZHIYA PHARMACEUTICAL CO LTD;
发明人 PAN ZHAOXI;BU XIAOFEI;WU RONGGUI;XUE FUZHAO;CHEN ZHENGQIAN;
申请号 CN20131422354
申请日 2013/9/12
公开日 2013/12/25
优先权号
IPC C07D209/08;
专利类型
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The invention relates to a preparation method of high-quality indapamide, in particular relates to a control method of impurity A, belonging to the field of a raw material medicine production technology. The method controls the water content of a reaction system and the anhydrous aftertreatment and uses methylene dichloride to replace tetrahydrofuran to be taken as a reaction solvent, thus not only lowering the production cost, but also reducing the amount of the impurity A
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