专利详细信息
专利号 | US2014024658A1 |
专利标题 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE |
专利权人 | MERCK PATENT GMBH [DE]; |
发明人 | BATHE ANDREAS [DE];HELFERT BERND [DE];NEUENFELD STEFFEN [DE];KNIEL HEIKE [DE];BARTELS MATTHIAS [DE];RUDOLPH SUSANNE [DE];BOTTCHER HENNING [DE]; |
申请号 | US201314032183 |
申请日 | 2013/9/19 |
公开日 | 2014/1/23 |
优先权号 | |
IPC | C07D405/00; C07D405/12; A61K31/496; A61P1/14; A61P3/04; A61P9/10; A61P9/12; A61P15/00; A61P15/10; A61P21/00; A61P25/04; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P29/02; |
专利类型 | |
法律状态查询 | 查看法律状态 |
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea,
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