专利详细信息
| 专利号 |
 |
| 专利标题 | ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS |
| 专利权人 | SINGH MANMOHAN [US];SKIBINSKI DAVID A G [SG];WU TOM YAO-HSIANG [US];LI YONGKAI [US];CORTEZ ALEX [US];ZHANG XIAOYUE [US];ZOU YEFEN [US];HOFFMAN TIMOTHY Z [US];PAN JIANFENG [US];YUE KATHY [US];IRM LLC [BM];NOVARTIS AG [CH]; |
| 发明人 | SINGH MANMOHAN [US];SKIBINSKI DAVID A G [SG];WU TOM YAO-HSIANG [US];LI YONGKAI [US];CORTEZ ALEX [US];ZHANG XIAOYUE [US];ZOU YEFEN [US];HOFFMAN TIMOTHY Z [US];PAN JIANFENG [US];YUE KATHY [US]; |
| 申请号 | US201113820370 |
| 申请日 | 2011/9/1 |
| 公开日 | 2013/10/17 |
| 优先权号 | |
| IPC | C07F9/6561; C07F9/645; C07F9/6512; C07F9/6558; |
| 专利类型 | |
| 法律状态查询 | 查看法律状态 |
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
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