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专利详细信息
专利号
US8410268B2
专利标题 Process for the preparation of ziprasidone
专利权人 Alkem Laboratories Limited;
发明人 Shridhara, Kanakamajalu;Mukherjee, Debkiron;Badraje, Padmashree;Rao, K Sundarraja;Nagarajan, Kuppuswamy;
申请号
申请日
公开日 2013/4/2
优先权号
IPC C07D41712000;
专利类型
法律状态查询 查看法律状态


The present invention relates to a process for preparing Ziprasidone of formula I or a pharmaceutically acceptable salt or a solvate or a hydrate thereof; comprising the steps of reacting 1-(12-benzisothiazol-3-yl) piperazine of formula II or its salt: with 5-(2-haloethyl)-6-chloro-oxindole of formula III: wherein X is leaving groups like fluoro chloro bromo iodo or sulphonyl; in the presence of a dispersing agent and a base in a solvent to form ziprasidone of formula I; and optionally converting the ziprasidone formed into a pharmaceutically acceptable acid addition salts of ziprasidone; or a solvate or a hydrate thereof.
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