专利详细信息
专利号 | US8410268B2 |
专利标题 | Process for the preparation of ziprasidone |
专利权人 | Alkem Laboratories Limited; |
发明人 | Shridhara, Kanakamajalu;Mukherjee, Debkiron;Badraje, Padmashree;Rao, K Sundarraja;Nagarajan, Kuppuswamy; |
申请号 | |
申请日 | |
公开日 | 2013/4/2 |
优先权号 | |
IPC | C07D41712000; |
专利类型 | |
法律状态查询 | 查看法律状态 |
The present invention relates to a process for preparing Ziprasidone of formula I or a pharmaceutically acceptable salt or a solvate or a hydrate thereof; comprising the steps of reacting 1-(12-benzisothiazol-3-yl) piperazine of formula II or its salt: with 5-(2-haloethyl)-6-chloro-oxindole of formula III: wherein X is leaving groups like fluoro chloro bromo iodo or sulphonyl; in the presence of a dispersing agent and a base in a solvent to form ziprasidone of formula I; and optionally converting the ziprasidone formed into a pharmaceutically acceptable acid addition salts of ziprasidone; or a solvate or a hydrate thereof.
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