The invention belongs to medical preparation relate to a kind of new phenytoin targeted nano preparation and preparation method thereof.The present invention take the P-glycoprotein monoclonal antibody as targeting head base take high molecular polymer as carrier makes the nanometer formulation of targeted therapy drug resistant epilepsy take phenytoin as effective ingredient.The present invention is by the ratio of Polyethylene Glycol and polycaprolactone in the change high molecular polymer drug loading and the rate of release of control phenytoin; Utilize slow release and initiatively the targeting technology to solve in the present phenytoin treatment drug resistant epilepsy blood-brain barrier permeability poor epileptic focus district drug level is low therapeutic effect is poor the problem of erious adverse reaction the safety that obviously improves phenytoin.But preparation target administration of the present invention is to the drug resistant epilepsy focal zone thereby greatly improves the phenytoin content of focal zone suppresses the outbreak of epilepsy.

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