The invention provides a kind of is the lepirudin 023 ludon eye drop and preparation method thereof of adjuvant with the hyaluronate sodium.Technical characterictic of the present invention is to include hyaluronate sodium in the lepirudin 023 ludon eye drop and it has and prevents that overflow of drug fluid runs off makes medicine be detained the effect of focal zone for a long time.The present invention has also announced the method for preparing of lepirudin 023 ludon eye drop and this method has guaranteed the clarity and the stability of eye drop.The lepirudin 023 ludon eye drop of the present invention's preparation is except that comprising lepirudin 023 ludon the hyaluronate sodium also comprising isoosmotic adjusting agent metal chelating agent antiseptic and pharmaceutically acceptable carrier.Concrete method for preparing is hyaluronate sodium isoosmotic adjusting agent metal chelating agent antiseptic to be dissolved in form the blank substrate of eye drop in the pharmaceutically acceptable carrier; Then lepirudin 023 ludon is dissolved in the blank substrate of eye drop; Filtration sterilization packing make the lepirudin 023 ludon eye drop.The lepirudin 023 ludon eye drop pH value that makes is 4.0～7.5.Pharmacodynamic experiment is the result show the lepirudin 023 ludon eye drop of the method for the invention preparation has the cataractous effect of control.

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