专利详细信息
专利号 | US20140088197A1 |
专利标题 | Mixed crystal agomelatine (form viii), preparation method and use thereof and pharmaceutical composition containing same |
专利权人 | LES LABORATORIES SERVIER; |
发明人 | Huang, Yu;Long, Qing;Zhu, Xueyan;Shan, Hanbin;Yuan, Zhedong;Yu, Xiong; |
申请号 | US14/006484 |
申请日 | 2012/3/22 |
公开日 | 2014/3/27 |
优先权号 | |
IPC | C07C23308000; |
专利类型 | |
法律状态查询 | 查看法律状态 |
The present invention provides a mixed crystalline form VIII of agomelatine its method of preparation application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests it has been found to be superior to the crystalline form VI in terms of stability. As a result the crystalline form VIII of the present invention possesses advantages in pharmaceutical preparation.
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