The invention discloses a kind of method that Split Method prepares the optical purity metoprolol belong to racemoid and split field.Take the chirality cyclic phosphoric acid as resolving agent prepare the optical purity metoprolol chirality cyclic phosphoric acid resolving agent can use separately also can mix use.Be specially the racemization metoprolol and chirality cyclic phosphoric acid resolving agent forms diastereomeric salt in solvent the diastereomeric salt that solubleness is less filters and filter cake obtains the optical purity metoprolol after dissociating; Filtrate obtains another isomer of metoprolol after dissociating.The characteristics that the inventive method has that photolytic activity metoprolol optical purity is high yield is high resolution reagent recoverable industrialization simple to operate and suitable amplify.

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