The invention discloses a kind of preparation method of metoprolol salt as raw material make solvent with water or ethanol with p-(2-methoxy ethyl) phenol and epoxy chloropropane under the effect of highly basic obtain 3-[4-(2-methoxy ethyl phenoxy group)]-12 epoxy prapane; Again with water as solvent 3-[4-(2-methoxy ethyl phenoxy group)]-12 epoxy prapane and Isopropylamine reaction obtain metoprolol alkali with the saturated monohydroxy alcohol solution reaction of organic acid saturated monohydroxy alcohol solution or hydrochloric acid obtain metoprolol salt again.This compound is used its hydrochloride succinate fumarate or tartrate clinically is treatment hypertension coronary heart disease chronic heart failure and ARR common drug.Preparation method's raw material of the present invention is cheap and easy to get and solvent for use is the second alcohol and water does not almost pollute and is easy to operate and the product purity of preparation is high and yield is high and cost is lower is fit to very much scale operation.

暂无附图