The invention discloses the oral timing and controlled release pellet preparations of Propranolol and salt thereof said preparation is comprised of slow release ball core alkaline layer and the sluggish layer that the rapid release ball core that contains 40～120mg Propranolol and salt thereof slow release layer alkaline layer sluggish layer form or contain 40～120mg Propranolol and salt thereof.Sluggish layer wherein contains polyacrylic resin III and its weightening finish is 80～200% of ball core; Alkaline layer is the medicinal soluble basic auxiliary and weight is 10～30% of ball core.The characteristics of said preparation are that oral rear medicine does not discharge immediately but begin slowly to discharge from micropill through 3～4 hours time hysteresis medicine and slow-release time reaches 12～16 hours can steadily control in the daytime blood pressure.In the time of can reaching steady control patient and awaken in the morning and tens hours endogenous cause of ill blood pressure purposes in the daytime.

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