The invention provides a kind of composite phospholipid carrier that can promote the absorption of Propranolol percutaneous and preparation method thereof it is by the phospholipid material of two kinds of different phase transition temperatures---dipalmitoyl phosphatidyl choline and soybean phospholipid as composite phospholipid material the Propranolol composite phospholipid carrier that thus prepared by phospholipid material with in prior art only adopt the carrier of single phospholipid material and compare envelop rate is significantly improved leak and reduce stability in rat plasma improves and percutaneous dosing artifact availability also significantly improves.By Propranolol composite phospholipid carrier provided by the invention be particularly useful for treating infant hemangioma can realize Propranolol transdermal administration and act directly on hemangioma affected part when improving curative effect reducing toxic and side effects improve the compliance of infant medication.The present invention simultaneously also provides the preparation method of this kind of Propranolol composite phospholipid carrier.

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