A kind of metoprolol fumarate sustained-release tablet and preparation method thereof is horse acid metoprolol 95g by principal agent; Framework material hydroxypropyl emthylcellulose 100～300g; Blocker ethyl cellulose or hyposmosis type acrylic resin 30～50g; Ethanol 100～the 300g of wetting agent 85%; Magnesium stearate lubricant 2.68g～4.02g and fluidizer Pulvis Talci 5.025～8.375g the preparation total amount is 1000 and takes medicine and be spaced apart the slow releasing tablet of 24h.Principal agent first with blocker again with the framework material mixing; With wetting agent soft material processed granulation drying granulate adds lubricant and fluidizer tabletting is up to the standards and namely obtains metoprolol fumarate sustained-release tablet.After taking sustained release not only reduces medicining times every day facilitate clinician and patient's medication and blood drug level is steady can not produce " peak valley " phenomenon makes toxic and side effects be down to floor level and patient compliance is good.

暂无附图