The invention discloses a kind of propranolol hydrochloride lipidosome gel it is to be made by crude drug and the adjuvant of following weight portion: propranolol hydrochloride 0.012%～0.075% PHOSPHATIDYL ETHANOLAMINE 0.037%～0.150% cholesterol 0.012%～0.075% triethanolamine 2.5%～5% carbomer 1%～2% surplus is water.Propranolol hydrochloride lipidosome gel of the present invention during preparation is dispersed in liposome in gel has improved the stability of liposome.Water-soluable gel carbomer has good biocompatibility can well attach to skin and can produce not stimulate skin.Propranolol hydrochloride lipidosome gel of the present invention when improving the drug administration time has reduced the toxic and side effects of whole body has improved patient's compliance therefore has good application prospect.

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