The invention provides a kind of coumpound diclofenac sodium and chlorphenamine maleate sheet and preparation method.By changing the accessory formula in original production process effectively improved the stability of coumpound diclofenac sodium and chlorphenamine maleate sheet solved coumpound diclofenac sodium and chlorphenamine maleate sheet and easily chapped and the unsettled quality problems of content in storage process.The ratio of adjuvant of production technology is: pregelatinized Starch 30 ~ 60% microcrystalline Cellulose 10 ~ 30% starch 10～20% hyprolose 10 ~ 20% sodium lauryl sulphate 0.1～0.5% carboxymethylstach sodium 1～5.5% surplus are lubricant.Coumpound diclofenac sodium and chlorphenamine maleate sheet prepared by the present invention unilateral smooth stable performance is applicable to large production and product quality meets the requirement of national drug quality standard.

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