专利详细信息
专利号 | SE506179C2 |
专利标题 | Farmaceutisk lågkomposition av benazepril och ett tiaziddiuretikum |
专利权人 | NOVARTIS AG; |
发明人 | Rosselet, Armel; |
申请号 | SE19900000050 |
申请日 | 1990/1/8 |
公开日 | 1997/11/17 |
优先权号 | |
IPC | A61K03154000; |
专利类型 | |
法律状态查询 | 查看法律状态 |
PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended when used alone. Bendroflumethiazide Chlorthalidone Chlorothiazide hydrochlorothiazide hydroflumethiazide methylchlorothiazide polythiazide trichloromethiazide benzthiazide and dichloroazide are cited as the thiazide diuretic agent. The most preferred composition comprises bezenapril hydrochloride and hydrochlorothiazide at about 0.8-1 weight ratio.
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