The invention discloses a kind of irinotecan hydrochloride lipid nanoparticle injection and method for making thereof with irinotecan hydrochloride and stearic acid being dissolved in organic solvent and lecithin dissolves in buffer salt solution and forms mixed phase the aqueous solution that is dissolved with PEG400 glycerol and trehalose of take is water adopt stirring and emulsifying and the even method combining of high pressure breast irinotecan hydrochloride bag is loaded in and in lipid nanoparticle makes irinotecan hydrochloride lipid nano particle preparation.Lipid nano particle preparation drug loading provided by the invention is high particle diameter even medicine retention time in blood circulation is long there is better slow release and controlled-release effect and the equipment of preparation method is simple easy operating improved product quality reduce toxic and side effects be suitable for industrialized great production.

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