专利详细信息
专利号 | US20140073804A1 |
专利标题 | Process for the preparation of zanamivir |
专利权人 | Cadila Healthcare Limited; |
发明人 | Charan, Ganpat Dan Shimbhu;Tehare, Ajay Onkarsingh;Singh, Kumar Kemlesh Laxmi; |
申请号 | |
申请日 | |
公开日 | 2014/3/13 |
优先权号 | |
IPC | C07D30928000; |
专利类型 | |
法律状态查询 | 查看法律状态 |
The present invention provides a process for preparing 5-(acetylamino)-4-[(aminoiminomethyl)amino]-26-anhydro-345-trideoxy-D-glycero-D-galacto-non-enonic acid Formula (I) which process comprises reducing compound of Formula (IV) by Lindlar catalyst in presence of hydrogen to obtain compound of Formula (V). reacting compound of Formula (V) with pyrazole-1H-carboxamidine or its suitable salt to obtain compound of Formula (VIII). hydrolyzing the compound of Formula (VIII) to give compound of Formula (I). The present invention also provides compounds of formula (VIII) which may be used in the synthesis of zanamivir. The present invention also provides process for preparing compound of formula (VIII) and process involving the use of Formula (VIII) including in the synthesis of zanamivir.
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