PROBLEM TO BE SOLVED: To obtain a highly pure acylpiperazine derivative hydrochloride or sulfonylpiperazine derivative hydrochloride.SOLUTION: When a piperazine derivative is acylated or sulfonylated to produce the acylpiperazine derivative hydrochloride or sulfonylpiperazine derivative hydrochloride a tertiary amine is added.COPYRIGHT: (C)2002JPO

PROBLEM TO BE SOLVED: To provide a method for isolating and retrieving succinic acid in a relevant succinate-containing solution in high purity at low cost and by an eco-friendly means. SOLUTION: A method for producing succinic acid enabling it to be isolated and retrieved in high purity at low cost and by an eco-friendly means is provided including the following process: cationic components are filtered off using a nanofiltration membrane from a relevant succinate-containing solution to effici...

PROBLEM TO BE SOLVED: To provide a method for adsorbing and separating a phenol compound by which the phenol compound can be brought into contact with an adsorbent in a liquid phase state without warmly keeping the phenol compound. SOLUTION: This method for adsorbing and separating 25-dichlorophenol from a dichlorophenol isomer mixture containing the 25-dichlorophenol is characterized by dissolving the dichlorophenol isomer mixture in 1-hexanol as a desorbent and then bringing the solution into...

PROBLEM TO BE SOLVED: To provide a high-purity N-monosubstituted piperazine by removing piperazine which is an impurity contained in the N-monosubstituted piperazine.SOLUTION: This method for purifying the N-monosubstituted piperazine is carried out as follows. A mineral acid or an organic acid is added to the N-monosubstituted piperazine represented by the general formula (1) (wherein R(sup 1) denotes an alkyl group an aralkyl group or an aromatic substituent) and distillation is then conducted...

PROBLEM TO BE SOLVED: To obtain a highly pure acylpiperazine derivative hydrochloride or sulfonylpiperazine derivative hydrochloride.SOLUTION: When a piperazine derivative is acylated or sulfonylated to produce the acylpiperazine derivative hydrochloride or sulfonylpiperazine derivative hydrochloride a tertiary amine is added.COPYRIGHT: (C)2002JPO

PROBLEM TO BE SOLVED: To obtain a piperazine amide compound under mild conditions in high yield.SOLUTION: A method for manufacturing the piperazine amide compound by carrying out the amidation between a carboxylic acid ester and a piperazine derivative while removing the generated alcohol by distillation or in the coexistence of water.COPYRIGHT: (C)2002JPO

PURPOSE: To provide a process for the separation of parapyruvic acids from a mikture of pyruvic acid or its salt containing parapyruvic acids in high separation efficiency and capable of separating and purifying pyruvic acid or its salt in high efficiency.CONSTITUTION: Pyruvic acid or its salt can be separated from a liquid mixture at least containing pyruvic acid or its salt and parapyruvic acids by permeating pyruvic acid or its salt using a reverse osmosis membrane.COPYRIGHT: (C)1994JPO

PROBLEM TO BE SOLVED: To obtain a curing agent for nicotine dependent diseases having no adverse effects and excellent in pharmaceutical effects and safety by bringing an opioid receptor-acting compound as an effective ingredient.SOLUTION: This curing agent for nicotine-dependent diseases contains an opioid receptor-acting compound expressed by the formula [a dotted line is a double bond or a single bond; R(sup 1) is a 1-5C alkyl a 4-7C cycloalkyl a 6-12C aryl etc.; R(sup 2) is H hydroxy nitro a...

PROBLEM TO BE SOLVED: To produce the subject compound useful as a raw material for medicines and agrochemicals cleaning agents for producing electronic materials or the like in high yield by distilling and purifying a lower alkyl ester of pyruvic acid in the presence of an epoxy group-containing compound and a quaternary ammonium group-containing compound.SOLUTION: When a lower alkyl ester of pyruvic acid (e.g. methyl pyruvate) is distilled and purified a compound having epoxy group (e.g. a bisp...

PROBLEM TO BE SOLVED: To produce the subject compound useful as a raw material for medicines and agrochemicals and cleaning agents or the like for producing electronic materials in good yield by neutralizing a mixture solution of a pyruvate with water a lower alcohol and 12-dichloroethane then heating the resultant mixture solution cooling the heated solution separating the formed crystal by filtration and azeotropically dehydrating the resultant system.SOLUTION: A mixture solution of an alkali ...