The present invention relates to: a benzyl derivative containing an activated vinyl group; a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound as an active ingredient. The benzyl derivative is effective as an agent for preventing and treating neurological disorders caused by nerve cell dysfunction and death particularly Parkinson's disease Alzheimer-type dementia Huntington's disease Lou Gehrig's disease epilepsy depression insomnia anxiety and ne...

The present invention relates to: a benzyl derivative containing an activated vinyl group; a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound as an active ingredient. The benzyl derivative is effective as an agent for preventing and treating neurological disorders caused by nerve cell dysfunction and death particularly Parkinson's disease Alzheimer-type dementia Huntington's disease Lou Gehrig's disease epilepsy depression insomnia anxiety and ne...

PURPOSE: A composition containing a pyrazolopyrimidine derivative compound for suppressing NO generation and a pharmaceutical composition containing the pyrazolopyrimidine derivative compound for preventing and treating neurological disorders are provided to suppress NO generation in vivo and to treat neurological disorders caused by functional disturbance and apoptosis of neural cells. CONSTITUTION: A pyrazolopyrimidine derivative compound of chemical formulas I-VII or a pharmaceutically accept...

Disclosed herein is a method for treating diseases associated with beta amyloid accumulation including administering to a patient a therapeutically effective amount of morpholine or piperazine based compounds including a sulfuric or carboxylic acid structure represented by the following chemical formula 1 or a pharmaceutically acceptable salt thereof: (wherein Z R1 and R2 are as defined in the specification).

PURPOSE: A Caryopteris incana extract a fraction thereof and a compound isolated from the extract or the fraction and a composition containing the same for protecting liver are provided to protect liver cells from hepatotoxicity caused by toxic materials and to prevent and treat liver diseases. CONSTITUTION: A pharmaceutical composition for a liver protective agent contains one or more kinds of compounds selected among compounds of chemical formulas 1-3 5 and 8-10. The compounds protect liver ce...

The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 67-dimethoxy-1234-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction an Aza-Prins cyclization reaction in the presence of an oxidant and an...

PURPOSE: A composition containing Dendrobium moniliforme is provided to prevent relieve or treat PPAR activation regulation-related diseases including obesity metabolic diseases and cardiovascular diseases. CONSTITUTION: A composition for preventing or treating PPAR activation regulation-related diseases contains Dendrobium moniliforme as an active ingredient. A composition for health functional food for preventing or treating PPAR activation regulation-related diseases contains Dendrobium monil...

Novel oxazolidinone derivatives with a difluorophenyl moiety represented by Chemical Formula 1 pharmaceutically acceptable salts thereof a preparation method thereof and a pharmaceutical composition containing the same as an active ingredient are provided. Exhibiting potent inhibitory activity against Gram-positive bacteria including Haemophilus influenza and Coagulase negative staphylococci and resistant bacteria including vancomycin-resistant enterococci (VRE) the pharmaceutical composition is...

PURPOSE: A method for preparing olmesartan cilexetil of a crystalline form is provided to industrially synthesize the compound with stability. CONSTITUTION: A method for preparing olmesartan cilexetil of a crystalline form comprises: a step of reacting 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylic acid and 1-chloroethyl cyclohexyl carbonate in a solvent to prepare 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylic acid-1-cyclohexyloxycarbonylic-ethyl ester; a step of cryst...

Disclosed herein is a method for treating diseases associated with beta amyloid accumulation including administering to a patient a therapeutically effective amount of morpholine or piperazine based compounds including a sulfuric or carboxylic acid structure represented by the following chemical formula 1 or a pharmaceutically acceptable salt thereof:(wherein Z R1 and R2 are as defined in the specification).