The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.

Disclosed are nitric oxide delivery agents and methods of their use more specifically to photoactive compounds which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including but not limited to blood pressure regulation and cancer treatment.

Niacin prevents and/or reverses the development of experimental hepatic steatosis deposition of triglycerides in liver and serum of individuals deposition of total cholesterol in liver and serum in individuals and inhibit liver lipid peroxidation and oxidative stress in individuals at risk of developing fatty liver disease or NAFLD. In cultured human hepatocytes niacin inhibits alcohol-induced fat accumulation.

The present application is related to compounds represented by Formula I which are novel positive allosteric modulators of al nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on al nAChRs in a mammal by administering an effective amount of a compound of Formula I.

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions kits and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition...

Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sulfamates and carbamates which are attractive cross-coupling partners particularly for use in multistep synthesis. Illustrative embodiments include versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines as exemplified by a ...

Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine telenzepine atropine or derivatives thereof or salts thereof or analogs thereof or derivatives thereof and a pharmacologically acceptable carrier. The composition may be injectable or alternatively may be applied topically or alternatively may be delivered orally. A suitable topica...

Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize unconventional phenol derivatives as cross-coupling partners. Embodiments of the invention can be used to synthesize a variety of useful organic compounds for example the anti-inflammatory drug flurbiprofen.

The disclosure provides a method for enhancing memory of a subject lowering blood glucose levels in a subject and treating schizophrenia the methods comprise intranasally administering to the subject an amount of a oxytocin peptide or analogue thereof having a beneficial effect.