Crystalline anhydrous hydrochloride salts of 45?-epoxy-314-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

Substituted nicotinamides processes for their preparation medicaments comprising these compounds and methods of using these compounds to treat pain epilepsy urinary incontinence anxiety dependency mania bipolar disorders migraine cognitive diseases and/or dystonia-associated dyskinesias.