A novel process for the synthesis of fenofibrate includes reacting a metal salt of fenofibric acid with an isopropyl halide in a solvent system composed of a mixture of dimethyl sulfoxide and a C2-C4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.

The present invention relates to a novel method for synthesizing fenofibrate. This method is essentially characterized in that it comprises reacting in a solvent system constituted of a mixture of dimethyl sulphoxide and of a C-Calkyl acetate a metal salt of fenofibric acid with an isopropyl halide. This method can be used on the industrial scale and makes it possible to obtain a fenofibrate having a quality in accordance with the pharmacopeia without the need for purification by recrystallizati...

A novel process for the synthesis of fenofibrate includes reacting a metal salt of fenofibric acid with an isopropyl halide in a solvent system composed of a mixture of dimethyl sulfoxide and a C2-C4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.