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TUFTS COLLEGE [US](95)
PARATEK PHARM INNC [US](21)
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公开号
公开日
申请号
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1.
US2013029943A1
2013/1/31
US201113312291
2011/12/6
专利标题
:Methods of Preparing Substituted Tetracyclines with Transition Metal-Based Chemistries
专利权人
:
TUFTS COLLEGE [US]
;
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, ...
2.
US2012283201A1
2012/11/8
US201213547870
2012/7/12
专利标题
:9-SUBSTITUTED MINOCYCLINE COMPOUNDS
专利权人
:
TUFTS COLLEGE [US]
;
PARATEK PHARM INNC [US]
;
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
3.
US8012951B2
2011/9/6
US20090356907D
2009/1/21
专利标题
:7-N-substituted phenyl tetracycline compounds
专利权人
:
TUFTS COLLEGE [US]
;
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
4.
EP2327686A2
2011/6/1
EP20100182808
2000/9/13
专利标题
:Methods of preparing substituted tetracyclines with transition metal-based chemistries
专利权人
:
TUFTS COLLEGE [US]
;
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetrac...
5.
EP2327687A2
2011/6/1
EP20100182806
2000/9/13
专利标题
:Methods of preparing substituted tetracyclines with transition metal-based chemistries
专利权人
:
TUFTS COLLEGE [US]
;
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetrac...
6.
US2011118215A1
2011/5/19
US19902011130125
2011/1/24
专利标题
:7,8 And 9-Substituted Tetracycline Compounds
专利权人
:
TUFTS COLLEGE [US]
;
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
7.
US2011086821A1
2011/4/14
US20100897459
2010/10/4
专利标题
:Tetracycline Compounds for Treatment of Cryptosporidium Parvum Related Disorders
专利权人
:
TUFTS COLLEGE [US]
;
Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.
8.
EP2308832A1
2011/4/13
EP20100182900
2001/6/29
专利标题
:9-Substituted minocycline compounds
专利权人
:
TUFTS COLLEGE [US]
;
PARATEK PHARM INNC [US]
;
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
9.
US2011082305A1
2011/4/7
US20100967906
2010/12/14
专利标题
:7-Phenyl-Substituted Tetracycline Compounds
专利权人
:
TUFTS COLLEGE [US]
;
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
10.
EA013908B1
2010/8/30
EA20040001579
2001/6/29
专利标题
:9-SUBSTITUTED MINOCYCLINE COMPOUNDS (EMBODIMENTS), A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATING A TETRACYCLINE RESPONSIVE STATE IN A MAMMAL
专利权人
:
TUFTS COLLEGE [US]
;
PARATEK PHARM INNC [US]
;
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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