3-pyrazole carboxylic acid amides, the preparation methods and the uses thereof in manufacture of the medicines as cannabinoid-1(CB1) receptor inhibitors are disclosed. The chemical structures of 3-pyrazole carboxylic acid amides are shown as the general formula (I) , wherein R1 is shown as formula (II): . The compounds have equivalent CB1 receptor inhibiting activity in vitro with Rimonabant, and remarkably reduced toxicity. The compounds can be used in manufacture of the medicines for detoxifi...