Methods are provided for making a diclofenac solution.

Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and acute pain such as photophobia, phonophobia, nausea and vomiting.

The present invention relates to a pharmaceutical formulation comprising mannitol and diclofenac or a pharmaceutically acceptable salt thereof in a particulate form at a weight ratio of greater than about 1.5:1.