The invention relates to a DGAT inhibitor of formula including any stereochemically isomeric form thereof a N-oxide thereof a pharmaceutically acceptable salt thereof or a solvate thereof and methods for preparing such compounds pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including but not limited to diabetes nephropathy neuropathy retinopathy polycystic ovary syndrome hypertension ischemia stroke irritable bowel disorder inflammation cataract cardiovascular diseases Metabolic X Syndrome hyper-LDL-cholesterolemia dyslipidemia (including hypertriglyceridemia hypercholesterolemia mixed hyperlipidemia and hypo-HDL-...

The present invention is directed to novel trisubstituted thiophene derivatives pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception the treatment and/or prevention of secondary dysmenorrhea amenorrhea dysfunctional uterine bleeding uterine leiomyomata endometriosis; polycystic ovary syndrome c...

The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis (2- 15 methoxyethoxy) aluminate (R...

The invention further relates to a DGAT inhibitor of formula (I) including any stereochemically isomeric form thereof wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents -NR

The invention relates to a DGAT inhibitor of formula (I) including any stereochemically isomeric form thereof wherein A represents CH or N; X represents O or NR

The invention relates to a DGAT inhibitor of formula (I) including any stereochemically isomeric form thereof wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents -O-C(=O)-; -C(=O)-C(=O)-; -NR