Peptide analogues of oxytocin are described together with methods of treating conditions ameliorated by modulating oxytocin receptor. The peptide analogues are seleno or telluro peptide analogues. Methods of synthesis of selenocysteine tellurocysteine and oxytocin analogues are also described.

The present invention relates to live attenuated Salmonella cultures for use as vaccines. The Salmonella cultures of the present invention have a substantially reduced capacity to grow and replicate in the presence of bile. The reduced capacity for growth is due to a metabolic-drift mutation induced by exposure to a combination of nalidixic acid and rifampicin for a time and under conditions sufficient to induce the mutation.

This invention discloses compositions and methods for inducing promoting or otherwise facilitating pain relief. More particularly the present invention discloses the use of sub-normovasodilatory doses of furoxan-containing nitric oxide donors in the therapeutic management of vertebrate animals including humans for the prevention or alleviation of pain especially neuropathic pain. According to some embodiments of the present invention furoxan-containing nitric oxide donors are administered by any...

This invention discloses compositions and methods for inducing promoting or otherwise facilitating pain relief. More particularly the present invention discloses the use of sub-normovasodilatory doses of furoxan-containing nitric oxide donors in the therapeutic management of vertebrate animals including humans for the prevention or alleviation of pain especially neuropathic pain. According to some embodiments of the present invention furoxan-containing nitric oxide donors are administered by any...

The present invention is directed to methods and compositions for inducing promoting or otherwise facilitating pain relief. More particularly the present invention discloses the combination of a nitric oxide donor and an opioid analgesic in the therapeutic management of vertebrate animals including humans for the prevention or alleviation of pain particularly moderate to severe pain. In particular the nitric oxide donor is a slow-release nitric oxide donor or is formulated to provide a sustained...

The present invention relates to live attenuated Salmonella cultures for use as vaccines. The Salmonella cultures of the present invention have a substantially reduced capacity to grow and replicate in the presence of bile. The reduced capacity for growth is due to a metabolic-drift mutation induced by exposure to a combination of nalidixic acid and rifampicin for a time and under conditions sufficient to induce the mutation.

This invention discloses compositions and methods for inducing promoting or otherwise facilitating pain relief. More particularly the present invention discloses the use of sub-normovasodilatory doses of nitric oxide donors in the therapeutic management of vertebrate animals including humans for the prevention or alleviation of pain especially neuropathic pain. According to some embodiments of the present invention nitric oxide donors are administered by any suitable route so as to provide conce...

The present invention is directed to methods and compositions for inducing promoting or otherwise facilitating pain relief. More particularly the present invention discloses the combination of a nitric oxide donor and an opioid analgesic in the therapeutic management of vertebrate animals including humans for the prevention or alleviation of pain particularly moderate to severe pain. In particular the nitric oxide donor is a slow-release nitric oxide donor or is formulated to provide a sustained...