The present invention is in the field of drug delivery and specifically cationic liposome-based drug delivery. In embodiments this invention provides methods of making ligand-targeted (e.g. antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors including brain tumors. In embodiments the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposo...

Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications including Alzheimer's disease Parkinson's disease dyskinesias Tourette's syndrome schizophrenia attention deficit disorder anxiety pain depression obsessive compulsive disorder chemical substance abuse alcoholism memory deficit pseudodementia Ganser's syndrome migraine pain bulimia obesity premenst...

Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction pain obesity schizophrenia epilepsy mania and manic depression anxiety Alzheimer's disease learning deficit cognition deficit attention deficit memory loss Lewy Body Dementia Attention Deficit Hyperactivity Disorder (ADHD) Parkinson's disease Huntington's disease Tourette's syndrome amyotrophic lateral sclerosis inflammation stroke spinal cord injury dyskinesias obsessive compuls...

Methods of treating preventing and ameliorating bacteria! infections with 12-benzisothiazolinone and isoindolinone derivatives are disclosed. Pharmaceutical compositions containing 12-benzisothiazolinone and isoindolinone derivatives are useful for treating bacteria! infections caused by drug resistant strains of bacteria including but not limited to methicillin and vancomycin bacterial organisms.

One aspect of the invention relates to piperidine compounds that are useful as inhibitors of monoamine transporters. The invention also relates to pharmaceutical compositions comprising a piperidine compound of the invention. Another aspect of the present invention relates to the use of the aforementioned compounds in a method of treating a disorder of the central nervous system in a mammal.

A method for the treatment of Cushing's syndrome in a patient in need thereof the method comprising administering to the patient an effective amount of a combination of a pharmaceutically acceptable salt of procaine and zinc sulfate heptahydrate at a frequency and for a duration of time sufficient to provide a beneficial effect to the patient.

One aspect of the invention relates to piperidine compounds that are useful as inhibitors of monoamine transporters. The invention also relates to pharmaceutical compositions comprising a piperidine compound of the invention. Another aspect of the present invention relates to the use of the aforementioned compounds in a method of treating a disorder of the central nervous system in a mammal.