Compounds of formula (I) wherein: the groups are as defined in the description are useful for the preparation of medicaments for the treatment of cardiovascular disorders in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+ K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain such as renal failure progression in autosomal dominant po...

The present invention provides a new process of synthesis of a polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline of Formula I. Said quinoline compound is substantially pure of any impurities. The present invention further provides the use of the above-mentioned polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline in the synthesis of piperaquine or one of its pharmaceutically acceptable salts.

Compounds of formula (I) wherein: the groups are as defined in the description are useful for the preparation of medicaments for the treatment of cardiovascular disorders in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+ K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain such as renal failure progression in autosomal dominant polycystic...

Compounds of formula (I) wherein: X is N; R1 is C1-C6 linear or branched alkyl or C1-C6 linear or branched alkenyl; R2 is hydrogen C1-C6 linear or branched alkyl or C1-C6 linear or branched alkenyl C6-C14 aryl or C6-C14 aryl(C1-C6) linear or branched alkyl or C6-C14 aryl(C1-C6) linear or branched alkenyl with the aryl group optionally substituted by one or more substituents either the same or different selected from the group consisting of halogen hydroxy C1-C6 alkoxy linear or branched or C114 ...

The use of acetyl L-carnitine in combination with propionyl L-~carnitine and sildenafil is described for the preparation of a medicament and/or dietetic product for the treatment of erectile dysfunction secondary to all those conditions in which there is distress or iatrogenic damage of the lesser pelvis within which the neurovascular bundles of the penis run.

The present invention provides a new process of synthesis of a polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline of Formula I. Said quinoline compound is substantially pure of any impurities. The present invention further provides the use of the above-mentioned polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline in the synthesis of piperaquine or one of its pharmaceutically acceptable salts.

Compounds of formula (I) wherein: X is N; R1 is C1-C6 linear or branched alkyl or C1-C6 linear or branched alkenyl; R2 is hydrogen C1-C6 linear or branched alkyl or C1-C6 linear or branched alkenyl C6-C14 aryl or C6-C14 aryl(C1-C6) linear or branched alkyl or C6-C14 aryl(C1-C6) linear or branched alkenyl with the aryl group optionally substituted by one or more substituents either the same or different selected from the group consisting of halogen hydroxy C1-C6 alkoxy linear or branched or C114 ...

It is described the use of thymosin alpha 1 in combination with long pentraxin PTX3 or Ganciclovir for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.