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Crystal Pharma, S.a.u.(10)
专利信息
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[专利权人] 包含 'Crystal Pharma, S.a.u.'
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申请日
1.
US20140011992A1
2014/1/9
US13/721204
2012/12/20
专利标题
:Synthesis of abiraterone and related compounds
专利权人
:
Crystal Pharma, S.a.u.
;
The present invention relates to processes for obtaining abiraterone and derivatives thereof such as abiraterone acetate by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C-C coupling through a steroid hydrazone of general formula (II) as well as to intermediates useful in said processes.
2.
EP2145882B1
2013/8/21
EP20080380218
2008/7/16
专利标题
:Process for obtaining olopatadine and intermediates
专利权人
:
Crystal Pharma, S.a.u.
;
3.
US20130203804A1
2013/8/8
专利标题
:Solifenacin salts
专利权人
:
Crystal Pharma, S.a.u.
;
The invention concerns fumarate salts of solifenacin as well as pharmaceutical compositions comprising fumarate salts of solifenacin. The invention furthermore concerns a process for preparing solifenacin and salts thereof. The fumarate salt provides improved properties over the known solifenacin salts especially in terms of its stability. The novel process for its preparation is furthermore improved over known processes for preparing solifenacin in that it provides a higher yield and recovers a...
4.
WO2013030410A3
2013/6/20
WO2012EP76380
2012/12/20
专利标题
:Synthesis of abiraterone and related compounds
专利权人
:
Crystal Pharma, S.a.u.
;
The present invention relates to processesfor obtaining abirateroneand derivatives thereof such as abiraterone acetate by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C-C coupling through a steroid hydrazone of general formula (II) as well as to intermediates useful in said processes.
5.
US20120004426A1
2012/1/5
US13/054210
2009/7/14
专利标题
:Process for obtaining olopatadine and intermediates
专利权人
:
Crystal Pharma, S.a.u.
;
Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II) wherein Y is OR1 wherein R1 is C1-C7 alkyl C3-C7 cycloalkyl aryl arylalkyl or heterocycle; or NR2R3 wherein R2 and R3 independently from each other are C1-C7 alkyl aryl arylalkyl or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members obtained by means of a process comprising reacting the corresponding ester or amide of 611-dihydro-11-oxo...
6.
US7875750B2
2011/1/25
US12/619651
2009/11/16
专利标题
:Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles
专利权人
:
Crystal Pharma, S.a.u.
;
The present invention relates to a process for preparing 2-amino-6-alkyl-amino-4567-tetrahydrobenzothiazoles (I) wherein the asterisk (*) represents an asymmetric carbon and R1 is C1-C6 alkyl; their enantiomers or mixtures thereof their solvates hydrates or pharmaceutically acceptable salts comprising: (a) reacting a compound (II) with a secondary amine optionally in the presence of an acid and a solvent 1 to form an enamine; (b) optionally removing said acid and said solvent 1 and then reacting...
7.
US20100063324A1
2010/3/11
US12/619651
2009/11/16
专利标题
:Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7- tetrahydrobenzothiazoles
专利权人
:
Crystal Pharma, S.a.u.
;
The present invention relates to a process for preparing 2-amino-6-alkyl-amino-4567-tetrahydrobenzothiazoles (I) wherein the asterisk (*) represents an asymmetric carbon and R1 is C1-C6 alkyl; their enantiomers or mixtures thereof their solvates hydrates or pharmaceutically acceptable salts comprising: (a) reacting a compound (II) with a secondary amine optionally in the presence of an acid and a solvent 1 to form an enamine; (b) optionally removing said acid and said solvent 1 and then reacting...
8.
EP2145882A1
2010/1/20
EP20080380218
2008/7/16
专利标题
:Process for obtaining olopatadine and intermediates
专利权人
:
Crystal Pharma, S.a.u.
;
Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II) wherein Y is OR 1 wherein R 1 is C 1 -C 7 alkyl C 3 -C 7 cycloalkyl aryl or heterocycle; or NR 2 R 3 wherein R 2 and R 3 independently from each other are C 1- C 7 alkyl aryl or R 2 and R 3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members obtained by means of a process comprising reacting the corresponding ester or amide of 611-dihydr...
9.
US7638542B2
2009/12/29
US11/571270
2005/6/24
专利标题
:Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydro-benzothiazoles
专利权人
:
Crystal Pharma, S.a.u.
;
A process for preparing 2-amino-6-alkyl-amino-4567-tetrahydrobenzothiazoles of formula (I)wherein the asterisk (*) represents an asymmetric carbon and R1 is C1-C6 alkyl; and enantiomers and mixtures thereof and their solvates hydrates and pharmaceutically acceptable salts. The process involves (a) reactingwith a secondary amine optionally in the presence of an acid and a first solvent to form an enamine; (b) optionally removing the acid and first solvent and then reacting the enamine with sulfur...
10.
US20070161798A1
2007/7/12
US11/571270
2005/6/24
专利标题
:Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7- tetrahydro-benzothiazoles
专利权人
:
Crystal Pharma, S.a.u.
;
The present invention relates to a process for preparing 2-amino-6-alkyl-amino-4567-tetrahydrobenzothiazoles (I) wherein the asterisk (*) represents an asymmetric carbon and R1 is C1-C6 alkyl; their enantiomers or mixtures thereof their solvates hydrates or pharmaceutically acceptable salts comprising: (a) reacting a compound (II) with a secondary amine optionally in the presence of an acid and a solvent 1 to form an enamine; (b) optionally removing said acid and said solvent 1 and then reacting...
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