A phenol derivative of the formula NU-A-X-R1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxy-indanyl hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene alkenylene or cycloalkylene which is interrupted by a heterocyclene linkage wherein R1 is hydrogen or alkyl alkenyl cycloalkyl halogenoalkyl aryl or arylalkyl or R1 is joined to R2 and wherein X is -CONR2- -CSNR2- -NR12CO- -NR12CS-...

Mono- or bis-complex esters or ethers of a phenol derivative of the formula NU-A-X-R1 wherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene alkenylene or alkynylene which may be interrupted by phenylene or other linkages wherein R1 is hydrogen or alkyl alkenyl cycloalkyl halogenoalkyl aryl or arylalkyl or R1 is joined to...

A phenol derivative of the formula NU-A-X-R1 wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl-hydroxyindanyl phenyl-hydroxybenzothienyl or mono-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene alkenylene or alkynylene which may be interrupted by phenylene or other linkages wherein R1 is hydrogen or alkyl alkenyl alkynyl cycloalkyl halogenoalkyl alkoxyalkyl halogenoalkoxyalkyl aryl or arylalkyl or R1 is joined to R2 and w...

A phenol derivative of the formula NU-A-X-R1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene alkenylene or alkynylene which may be interrupted by phenylene or other linkages wherein R1 is hydrogen or alkyl alkenyl cycloalkyl halogenoalkyl aryl or arylalkyl or R1 is joined to R2 and wherein X is -CONR2- -CSNR2- -NR12CO- -NR1...

The invention concerns novel esters of 4-(1-hydroxy-2-[(acylamino)alkylamino]ethyl)phenols of the formula: I and salts thereof wherein R1 and R2 are (3-5C)alkyl R3 and R4 are hydrogen or methyl A is a direct bond or methylene and Q is various heteroaromatic containing groups.The esters possess topical anti-inflammatory properties and the invention provides pharmaceutical compositions containing the esters and processes for their chemical manufacture.(From US4520027 A)

1486869 Compositions containing pyridoquinolines IMPERIAL CHEMICAL INDUSTRIES Ltd 21 April 1976 [19 May 1975] 21290/75 Heading A5B [Also in Division C2] Theropeutic compositions comprise compounds of formulae wherein R1 is H or the same as R2; R2 is CH 2 R CHMeR or CHEtR R being CN C 2-4 alkanoyl benzoyl C 2-6 alkanolyloxy (C 1-5 - alkoxy) carbonyl Ph-(C 1-3 alkoxy) carbonyl or C 3-7 -(dialkylcarbamoyl); and benzene ring B may be substituted by C 1-6 alkyl C 1-6 alkoxy or/and halogen.They ...

1487535 Compositions containing pyridoquinolines IMPERIAL CHEMICAL INDUSTRIES Ltd 15 April 1976 [19 May 1975] 21291/75 Heading A5B [Also in Division C2] Therapeutic compositions comprise compounds of formulae: wherein R' and R2 are different C 1-6 alkyl groups and benzene ring B may be substituted by C 1-6 alkyl C 1-6 alkoxy or/and halogen.They may be administered orally by inhalation or intravenously to treat intrinsic (non-allergic) asthma or a disease or syndrome initiated by antigen-antib...