The present invention provides a sterile solution comprising octreotide acetate in a pharmaceutically acceptable vehicle wherein solution is present as a reservoir in a multiple dose pen injection device the device being adapted to subcutaneously inject a portion of the said reservoir in multiple daily doses and further being adapted to provide multiple portions of the said solution while the reservoir remains sterile.

The present invention provides a sterile solution comprising octreotide acetate in a pharmaceutically acceptable vehicle wherein solution is present as a reservoir in a multiple dose pen injection device the device being adapted to subcutaneously inject a portion of the said reservoir in multiple daily doses and further being adapted to provide multiple portions of the said solution while the reservoir remains sterile.

The present invention provides a process for the preparation of amorphous rabeprazole sodium said process comprising (a) suspending rabeprazole in an organic solvent having dielectric constant ranging between 1.8 to 21 wherein at least 80 % of the organic solvent is a ketonic solvent having dielectric constant ranging between 13 to 21; (b) adding aqueous sodium hydroxide; (c) azeotropically distilling out water from the above reaction system to obtain a residue (d) adding ketonic solvent having ...

A pharmaceutical dosage form comprising a mixture of a therapeutically effective amount of oxcarbazepine having median particle size ranging from about 15 µm to about 26 µm and one or more hydrophilic polymers said mixture being formed by subjecting a suspension comprising said oxcarbazepine and a hydrophilic polymer in a solvent to mixing in a homogenizer optionally removing the solvent and converting the said mixture into a dosage form.

La présente invention fournit un système osmotique de délivrance contrôlée de médicament oral constitué- (a) d'un coeur constitué d'un mélange homogène de glipizide d'un polymère hydrophile et d'autres excipients pharmacologiquement acceptables. (b) d'une paroi semi-perméable entourant le coeur ladite paroi étant imperméable au contenu du coeur mais perméable aux fluides présents dans l'environnement d'utilisation et (c) d'une voir de passage à ...

A novel method for the synthesis of piperazine and its derivatives of formula 1wherein R is selected from hydrogen or a lower alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms;R1 is selected from hydrogen a methyl group a phenyl group optionally substituted with an alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms; andR2 is selected from hydrogen or a methyl group or a fluoromethyl group...

In the case of a multiple gear gearbox the loose gear of one of two immediately adjacent permanently engaged gear pairs is supported on the axially extended hub of the loose gear of the other gear pair and carries its shift dogs on the end face remote from the latter loose gear. Its shift dogs are arranged on the free end of the extended hub. In order to permit the transmission of high torques by means of a simple design with few components a small overall axial length and high reliability an ax...

A novel method for the synthesis of piperazine and its derivatives of formula 11wherein R is selected from hydrogen or a lower alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms;R1 is selected from hydrogen a methyl group a phenyl group optionally substituted with an alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms; andR2 is selected from hydrogen or a methyl group or a fluoromethyl grou...