Disclosed are methods and compositions combining the anti-inflammatory tetrahydro iso-alpha acids (THIAA) from hops with niacin for improving endothelial function. The THIAA/niacin mixture inhibited various TNF-a-induced cytokines in human aortic endothelial cells and in THP-1 monocytic cells and was significantly more efficacious than niacin alone. The effects of THIAA and niacin on endothelial-regulated flow-mediated vasodilation (FMD) was tested in dyslipidemic volunteers. The 12-week treatme...

C: \NRPortbl\DCC\DAR\489270_l.DOC-17 12/2012 Disclosed are botanically based compositions and methods useful for the treatment of metabolic syndrome and diabetes type 2. Compositions kits and methods are additionally disclosed for means to augment the activity of identified glucose and insulin regulating drugs. Hexahydrocolupulone _-^-7.1 0.57 Spent Hops : 1.11 Beta-Acids 1 .24 Alpha Acids sw ____ _ -' 1 1.45 -_- I _ _ ii _ Xanthohumol rrImm mm - 1.46 Hexahydroisoalpha acids Ir:".E 2 Tetrahydroi...