The present invention is directed to the oral osmotic delivery of therapeutic compounds that have limited solubility in an aqueous environment due to inherent hydrophobicity or to saturation limitations in the core of the osmotic system. The present invention is suitable for the osmotic delivery of glipizide and other hydrophobic drugs but runs the spectrum to other therapeutic agents with higher aqueous solubilities yet having a solubility limitation in an osmotic dosage unit due to high drug l...

Disclosed are once-daily formulations containing tetracyclines especially doxycycline. Such formulations are useful for instance for the treatment of collagenase destructive enzyme-dependent diseases such as periodontal disease and acne and acute and chronic inflammatory disease states such as rosacea and arthritis.

A fibrate self-emulsifying oral formulation with improved bioavailability when compared to commercially available formulations containing a therapeutically effective dose of fenofibrate derivative of fenofibrate or mixtures thereof dissolved in a fibrate solubilizer selected from N-alkyl derivative of 2-pyrrolidone mono- or di- or polyethylene glycol monoethers C8-12 fatty acid mono- or di-esters of propylene glycol or combinations thereof one or more surfactants and optionally one or more stabi...

A fibrate self-emulsifying oral formulation with improved bioavailability when compared to commercially available formulations containing a therapeutically effective dose of fenofibrate derivative of fenofibrate or mixtures thereof dissolved in a fibrate solubilizer selected from N-alkyl derivative of 2-pyrrolidone mono- or di- or polyethylene glycol monoethers C8-12 fatty acid mono- or di-esters of propylene glycol or combinations thereof one or more surfactants and optionally one or more stabi...

A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent such as selegiline in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a hydrophobic matrix. A hydrophilic microenvironment is created in a hydrophobic matrix by incorporating hydrophilic polymers within a hydrophobic matrix. Optionally a binder preferably a polyhydroyxlated compound can also be added.