The present invention relates to a method useful for forming products which are useful in a pharmaceutical context and products formed by such a method. The invention is a solvent-free method of forming a metastable polymorph of a pharmaceutical active ingredient the method comprising the steps of: placing an amorphous or crystalline compound into an extruder; providing a source of heat to the extruder to heat the compound to a temperature in the range of from 8 °C below the melting point of th...

A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallise in hexanol and the product thereof to crystallise in methanol and then derivatising the product of the methanol crystallisation to prepare said first isomer in very high purity.

A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallise in hexanol and the product thereof to crystallise in methanol and then derivatising the product of the methanol crystallisation to prepare said first isomer in very high purity.

A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallise in hexanol and the product thereof to crystallise in methanol and then derivatising the product of the methanol crystallisation to prepare said first isomer in very high purity.